Kambo, Micro-Dosing and Its Mysterious Background - Truffle Report
Now Reading
Kambo, Micro-Dosing and Its Mysterious Background

Kambo, Micro-Dosing and Its Mysterious Background

Kambo, comes from a green tree frog native that is typically found in the Amazon basin. The venomous section is referred to as Phyllomedusa Bicolor. It can be found exclusively in South America, including eastern Peru, Brazil (specifically rainforest regions in the north), Southeastern Columbia. Bolivia, Venezuela, and the Guiana’s. The term sapo refers to both the frog and its secretion. In recent years, the non-Western world has seen a rise in Micro-Dosing of Kambo.


Tree Frog


The use of Kambo can be traced back to the Panoan-speaking Indigenous groups in the Amazon rainforest, in Brazil. These early users claimed that it helped to aid fertility, increases strength and bring good luck on hunts. Some other uses include removing bad spirits, and including abortion. Yet, in the early 20th Century, it made its way to more urban parts of Brazil. The use of the substance can also be found in classical Maya civilizations, as early art depicts tree frogs next to mushrooms .

Within the rainforest, Kambo is used to aid hunting as it reduces the need for food or water. Hunters even claim that it emits a green light that guides them towards their prey . In 1925, French missionary Constantin Tastevin was staying in the Amazon and is cited as the first Westerner to use Kambo.


Journalist Peter Gorman and anthropologist Katharine Milton rediscovered Kambo in the 80s while spending time in Brazil and Peru. The two then supplied samples to two biochemists who discovered great medical potential within the substances . Despite the medical potential, few medications take use of the properties . It was not until 1994, that non-Indians began using Kambo. Francisco Gomes a half-Katukina caboclo began applying the drug to non-Indians in São Paul.


The largest effect would be the purging and deliberate vomiting that typically occurs after ingesting Kambo.

Personal Growth

Kambo is used for holistic treatment, alongside ayahuasca, ibogaine, 5-MeO-DMT and some other plant medicines .

The “detox” element that is typically marketed is based on the notion that Kambo resets the body, through strengthening the immune system and create psycho-spiritual benefits. Within Indigenous use, it is known to clear ones self of Panema. Panema is a term used the Ashaninka tribe, and refers to a negative energy within ones
self that accumulates over time. This negative energy can include bad luck, depression, irritation, laziness and other negative qualities.

Since the marketing of removing one’s Panema is difficult in the West, Kambo is typically advertised as a more general detox through marketing phrases such as “clearing the pain body” and “realigning the chakras”.

The pursue aspect of Kambo is seen as the release of these bad energies . After use, many users felt an increase in compassion, courage, emotional stability and personal sovereignty. They described an experience of being more grounded physically within their bodies, rather than in their heads. The duration of these changes varies – lasting anywhere from several days to several months . There is also a use of the substance for terminally ill patients, as it allows them to become more at ease with the notion of death. Research shows that patients have “seen the other side” after using Kambo .

Therapeutic use in a more medical context, Kambo can help with the treatment of cancer. Cancer cell growth has slowed by over 90% through the use of Dermaseptin B2. This is done through necrosis (active destruction) as opposed to apoptosis (normal or programmed cell death) . These qualities are highly powerful antibiotics, helping with a plethora of parasitic microorganisms. For example, late-stage HIV patients, have seen benefits from Kambo based on its ability to cross the blood-brain barrier .

Yet, its ability to cross the blood-brain barrier makes it beneficial in a number of illnesses. Uses have been applied to people with Alzheimer’s, depression and strokes. There has been formal research justifying its uses to treat anxiety, addiction and depression . Other treatments include Chronic Fatigue Syndrome, where one user saw a complete erasure of CFS symptoms follows a regular usage . Phylllokinin with Kambo can also help with hypertension, and has proven to help lower blood pressure . Other conditions which are proven to be aided by the use of Kambo include Parkinson’s, vascular problems, hepatitis, diabetes, rheumatism and arthritis.

The sale and marketing of Kambo in Brazil was prohibited in 2004 . As well, import is illegal in Chile . However, it is legal in the US and most other countries .

The secretion from the frog creates a chemical compound called Peptides. Peptides are short chains of amino acids, often between two to fifty . The specific Peptides found in the frog region include Dermorphins and Deltorphins. These types of Peptides then bind themselves to opioid receptors, sauvagine, vasodilator and dermaseptin . Then, an antimicrobial property called in vitro is created. However, phyllomedusin, phyllocaerulein, phyllokinin, caerulein, and adrenoregulin are also present . Receptor Binding Phyllocaerulein, a neuropeptide found in Kambo. It helps to stimulate thepituitary gland as well as the adrenal cortex. A typical amount is approximately 32 micrograms per milligram . Phyllomedusin, another compound helps to interact with tachykinin receptors. Tachykinin receptors help to regulate the dopamine, serotonin and many other neurotransmitters . Phyllomedusin contracts smooth muscles in ones body where phyllokinin helps to relax them . Again, this ability to helps to increase the permeability of the blood-brain barrier. Phyllomedusin contains 22 micrograms per milligram within Kambo.
Alternately, Phylllokinin contains around 18 micrograms per milligram.

Sauvagine, present only in 3 micrograms per milligram, functions similarly to a hormone. It connects with the pituitary-adrenal axis and corticotropin- releasing receptors which are highly connected to anxiety, stress, depression as well as addictive behaviour. Adenoregulin helps to stimulate the binding of agonists to A1 adenosine receptions . As a result in early testing, behavioural depression has been shown in mice.

Both deltorphins and dermorphins are powerful opiod receptors agonists . This is due to their high binding affinity and selectivity to delta opioid receptors within natural compounds. Deltorphins is present in 5.2 micrograms per milligrams where Deltorphins is 0.25-0.33 micrograms per milligram .Safety and Toxicity In terms of long-term effects, limited research is available. However, respiratory depression and frequent use can cause heavy reliance . The deaths related to Kambo have been because of the secretion’s depressive effects on the body’s central nervous system. Myths Perhaps the greatest myth surrounding Kambo is that it is hallucinogenic. Yet, not one of the peptides within Kambo are known to produce hallucinogenic effects. The only explanation for Kambo causing hallucinogens is that many taking Kambo alongside hallucinogenic substances such as nu-nu snuff .


What is Kambo Microdosing ?

Kambo Microdosing is the use of Kambo at a highly reduced amount. Typically, Kambo Micro-Dosers use around 1-2 mg of the substance as opposed to the typical 15 mg . Many choose to micro-dose Kambo as at a reduced dose, one will not feel the side effects. For example, with only 1-2 mg of Kambo, one is highly unlikely to purge or have irritable bowels . Additionally, micro-dosing is a responsible way to slowly acquaint ones body with Kambo. At such a small dosage, the effects are less significant.

The Science of Kambo Microdosing.

With micro-dosing with Kambo, users will not feel the intense side effects such as purging, a raise in heart rate and excessive heat. However, the more energetic side effects such as heightened sense, clear mind and clean slate will still be present .

How do you Microdose with Kambo?

See Also

Users are recommended to fast two hours prior to using, and eating lightly for the entirety of the day .

Unlike substances like Peyote or San Pedro where tea or powder is the preferred method, micro-dosing Kambo is quite unique in its form. In terms of going about using Kambo, a small gate will be opened on ones skin . There are three possible openings on ones body to administer the Kambo: forearm, upper arm or above the ankle. Some users have taken to different methods of consumption with Kambo while micro-dosing. For example, some claimed to have snorted the secretion up their nose as a powder rather than the gate in one’s skin. The user claimed that her heart went up, but not significantly. Her face went a little red, but nothing crazy. These physical effects only lasted five minutes until her body reset to normal. Additionally, no
purging happened during the micro-dosing . However, many reject the use of snorting Kambo, even with a low dose, as some believe it can lead to a “frog disease”. However, despite the correlation between snorting and frog disease, many users only observed a slight soreness in their nose for up to a day after snorting the substance. Many mico-dosers of Kambo who snort the substance suggest mixing the 1 mg of Kambo with a filler substance to make a diluted Kambo powder. However, snorting Kambo is only safe with small amounts, 1-2 mg, so the purchase of a digital scale to ensure property safety is recommended . Therefore, the more traditional burn method is safer as the skin will only absorb a portion of the Kambo that is administered onto the skin.

Thus,especially for beginners, administering Kambo to the skin is a much more low-risk option.

How do I acquire Kambo for Microdosing ?

The easiest method of Kambo Microdosing would be the purchase of a Kambo stick. These are easily purchasable online at places like World Herbals or Maya Ethnobotanical’s. Additionally, few locations around the world (Las Vegas, New York, Germany, Seattle) offer guided Micro-Dosing Kambo ceremonies for those who want the full experience.

Can Kambo be detected in a blood test?

Highly unlikely. Peptides are quite difficult to test for. While Kambo does contain Dermorphin, this can only be detected through a specialist lab, not a typical blood test .

Is microdosing illegal?

No, due to the legality of Kambo, microdosing would not be considered an illegal activity.

Is microdosing safe?

Micro-Dosing is obviously much safer than taking a full dosage of Kambo.
However, risks still apply. Therefore, the purchase of a digital scale to ensure one is taking a proper dosage is recommended. Additionally, to properly ensure one’s safety, perhaps a guided Kambo micro-dosing ceremony would be superior to administering on ones own.

View Comments (0)

Leave a Reply

Your email address will not be published.

© 2020 Truffle Report. All Rights Reserved.

Scroll To Top